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Neutrophilic Dermatoses: a Clinical Update.
Emma H Weiss1, Christine J Ko1, Thomas H Leung2
1Department of Dermatology, Yale School of Medicine, New Haven, CT USA.
Current Dermatology Reports
|March 21, 2022
Summary
Neutrophilic dermatoses involve sterile neutrophil buildup in skin, impacting various conditions like Sweet syndrome. Understanding their complex causes and associations guides new targeted therapies.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Neutrophilic dermatoses are characterized by sterile neutrophilic infiltration in skin.
- This review examines four key conditions: Sweet syndrome, pyoderma gangrenosum, Behçet syndrome, and neutrophilic eccrine hidradenitis.
Purpose of the Study:
- To review the pathogenesis, epidemiology, clinicopathological features, diagnosis, and management of four neutrophilic dermatoses.
- To synthesize recent findings on the complex mechanisms driving these conditions.
Main Methods:
- Literature review of recent studies on neutrophilic dermatoses.
- Synthesis of information on pathogenesis, clinical presentation, and treatment.
Main Results:
- Pathogenesis involves neutrophil function, inflammasome activation, genetic factors, and potential malignant transformation.
- These conditions present with diverse skin and systemic symptoms, linked to infections, inflammation, cancers, and drug reactions.
Conclusions:
- Neutrophilic dermatoses require comprehensive diagnostic approaches.
- Biologic and targeted anti-inflammatory therapies represent emerging treatment options.
Keywords:
Acute febrile neutrophilic dermatosisBehçet diseaseNeutrophilic dermatosisNeutrophilic eccrine hidradenitisPyoderma gangrenosumSweet syndromeMore Related Videos
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