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Related Experiment Video

Updated: Sep 29, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Histopathological Examination and Endoscopic Sinusectomy: Is It Possible?

Sara Vertaldi1, Pietro Anoldo2, Grazia Cantore1

  • 1Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.

Frontiers in Surgery
|March 21, 2022
PubMed
Summary

Histopathological examination of pilonidal sinus samples is feasible after minimally invasive endoscopic ablation (VAAPS). This study found no evidence of malignancy in 45 patients, confirming the safety and diagnostic capability of this approach for pilonidal sinus disease.

Keywords:
EPSiTVAAPShistopathological examination (HPE)malignant degenerationpilonidal disease

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Area of Science:

  • Surgical Oncology
  • Minimally Invasive Surgery
  • Pathology

Background:

  • Carcinomatous degeneration of pilonidal cysts is rare but necessitates histopathological examination.
  • Minimally invasive techniques for pilonidal sinus disease often preclude specimen retrieval for pathology.

Purpose of the Study:

  • To evaluate the feasibility of histopathological examination of pilonidal sinus excision material after endoscopic ablation.
  • To determine if minimally invasive techniques compromise the ability to perform histopathology for pilonidal sinus disease.

Main Methods:

  • A retrospective study of 45 patients with pilonidal sinus disease treated with Video Assisted Ablation of Pilonidal Sinus (VAAPS).
  • All patients underwent subsequent histopathological examination of the retrieved sinus sampling material.

Main Results:

  • Histopathological examination was successfully performed on samples from all 45 patients.
  • No evidence of malignancy was detected in any of the examined pilonidal sinus samples.
  • The study included Caucasian patients under 50 years old, with 9 cases of recurrent disease.

Conclusions:

  • Minimally invasive endoscopic ablation (VAAPS) for pilonidal sinus disease does not prevent histopathological examination.
  • The diagnostic integrity of histopathology is maintained even with minimally invasive approaches, ensuring safety and ruling out malignancy.