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Risk factors of re-bleeding within a year in colonic diverticular bleeding patients

Takahiro Gonai1, Yosuke Toya1, Keisuke Kawasaki1

  • 1Division of Gastroenterology, Department of Internal Medicine, School of Medicine Iwate Medical University Iwate Japan.

DEN Open
|March 21, 2022
PubMed

Insights

Antithrombotic agents (ATs) increase the risk of re-bleeding within a year for patients with colonic diverticular bleeding (CDB). This finding highlights the importance of careful consideration of AT use in CDB management.

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Epidemiology

Background:

  • Colonic diverticular bleeding (CDB) is a frequent cause of lower gastrointestinal bleeding.
  • Limited data exists on the impact of antithrombotic agents (ATs) on CDB recurrence.
  • Understanding re-bleeding risk factors is crucial for patient management.

Purpose of the Study:

  • To identify risk factors for CDB re-bleeding within one year.
  • To evaluate the association between antithrombotic therapy and CDB recurrence.

Main Methods:

  • Retrospective analysis of 76 patients diagnosed with CDB between 2015 and 2019.
  • Cox proportional hazard models were used to determine risk factors for re-bleeding.
  • Patients were categorized based on antithrombotic agent use and re-bleeding events.

Main Results:

  • Twenty-six out of 76 patients experienced re-bleeding within a year.
  • Patients with re-bleeding were more frequently treated with ATs (62% vs. 32%, p=0.013).
  • Antithrombotic therapy was an independent risk factor for re-bleeding (HR 3.89, p=0.004).

Conclusions:

  • Antithrombotic agents are an independent risk factor for one-year re-bleeding in CDB patients.
  • Careful management of ATs is warranted in patients with a history of CDB.
Abstract

Keywords:
antithrombotic therapycolonic diverticular bleedingcolonic diverticular hemorrhagediverticular diseaselower GI bleeding

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