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Clinical Characteristics of Antinuclear Antibody-Negative Systemic Lupus Erythematosus: A Systematic Review.

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Updated: Sep 29, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Jaccoud-type lupus arthropathy.

Mittermayer B Santiago1

  • 1Serviços Especializados em Reumatologia da Bahia, Salvador, Bahia, Brazil.

Lupus
|March 21, 2022
PubMed
Summary

Jaccoud's arthropathy in systemic lupus erythematosus (SLE) affects about 5% of patients, causing reducible joint deformities. Current treatments are limited, highlighting the need for further research to improve patient quality of life.

Area of Science:

  • Rheumatology
  • Immunology
  • Orthopedics

Background:

  • Jaccoud's arthropathy (JA) is characterized by reducible joint deformities, historically linked to rheumatic fever but now predominantly seen in systemic lupus erythematosus (SLE).
  • This condition significantly impacts patients' daily activities and quality of life.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, histopathology, clinical features, imaging, and management of Jaccoud-type lupus arthropathy (JLA).

Main Methods:

  • A literature search was conducted on PubMed using terms like "lupus arthropathy" and "Jaccoud's" from 1950 to March 2021.
  • No language restrictions were applied to the search.

Main Results:

  • Jaccoud-type arthropathy occurs in approximately 5% of SLE patients.
Keywords:
arthritisjoint diseasessystemic lupus erythematosus

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  • Common deformities include ulnar deviation, swan neck, and thumb "Z" deformity, with no validated classification criteria.
  • While plain radiographs show no bone erosion, advanced imaging like MRI and ultrasound may detect small erosions. Etiopathogenic mechanisms remain unknown.
  • Currently, there are no preventive measures, specific clinical treatments, or effective surgical options for JA deformities.

    • Conclusions:

    • Further research is urgently needed to address the management and treatment of Jaccoud's arthropathy in SLE patients.
    • Improving quality of life for affected individuals is a key unmet need.