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Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection
Julie A Bettke1,2, Jason W Tam1,2, Valeria Montoya1,2
1Department of Microbiology and Immunology, Renaissance School of Medicine at Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Infection and Immunity
|March 21, 2022
Summary
Inflammatory monocytes are crucial for controlling persistent salmonellosis by forming granulomas. Their depletion leads to disease progression, highlighting their therapeutic potential for granulomatous diseases.
Area of Science:
- Immunology
- Microbiology
- Pathology
Background:
- Persistent infections require balancing immunity and immunopathology.
- Inflammatory monocytes play a complex role in host defense.
Purpose of the Study:
- To investigate the role of inflammatory monocytes in host defense against persistent salmonellosis using a murine model.
- To understand how inflammatory monocytes influence granuloma formation and control of Salmonella.
Main Methods:
- Utilized a murine model of persistent salmonellosis.
- Manipulated inflammatory monocyte recruitment and depletion at different infection stages.
- Analyzed granuloma structure and pathogen burden.
Main Results:
- Impaired monocyte recruitment or depletion increased susceptibility to persistent infection.
- Inflammatory monocytes are key components of pathogen-containing granulomas.
- Monocyte depletion during chronic infection led to granuloma regression and pathogen dissemination.
Conclusions:
- Inflammatory monocytes are essential for granuloma-mediated control of persistent salmonellosis.
- These cells are critical for host defense and preventing pathogen spread.
- Targeting inflammatory monocytes may offer new therapeutic strategies for granulomatous diseases.
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