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Updated: Sep 29, 2025

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Comparisons of Ribonuclease HI Homologs and Mutants Uncover a Multistate Model for Substrate Recognition

James A Martin1, Arthur G Palmer2

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027, United States.

Journal of the American Chemical Society
|March 21, 2022
PubMed
Summary

Ribonuclease HI enzyme activity is linked to its handle region dynamics. Asparagine at position 88 leads to complex conformational states, unlike the simpler open/closed states seen with arginine or lysine.

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