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Updated: Sep 29, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Trends and associated risks in adolescent substance use: E-cigarette use and nitrous oxide use
1Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the Netherlands.
Abstract:
Two new trends in adolescent substance use have emerged: e-cigarette use and nitrous oxide (N20) use. E-cigarettes are often tried out before traditional cigarettes, are easily available and regarded as harmless by adolescents. Studies increasingly show negative health effects of regular e-cigarette use, including the risk of becoming a smoker of traditional cigarettes and nicotine addiction. N20 use has also become increasingly popular, and follows after cannabis and ecstasy use in prevalence rates. As with e-cigarette use, most users are not aware of potential health risks of N20 use, while particularly longer-term and heavy use may yield negative neurological and psychiatric effects. The misconception of risks, and high availability of both inhalants warrant better education to prevent poor outcomes.
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