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Improving Anxiety Screening in Patients with Turner Syndrome
Eirene Alexandrou1,2, Sarah Corathers3,4, Iris Gutmark-Little3,4
1Division of Endocrinology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Hormone Research in Paediatrics
|March 21, 2022
Summary
Anxiety is highly prevalent in Turner syndrome (TS) females, with 65% scoring elevated. Routine screening using tools like PROMIS® Anxiety is crucial for early detection and management in TS clinics.
Area of Science:
- Endocrinology
- Psychiatry
- Genetics
Background:
- Turner syndrome (TS) is a chromosomal condition affecting females, associated with neurocognitive and psychological challenges, including increased mood disorder prevalence.
- Current guidelines advocate for validated tools to screen for mental health conditions in individuals with TS.
Purpose of the Study:
- To implement and evaluate a routine anxiety screening approach in Turner syndrome patients.
- To determine the prevalence of anxiety, explore genotype-phenotype correlations, and assess the impact of comorbidities on anxiety in TS.
Main Methods:
- A pilot study utilizing the self-administered Patient-Reported Outcomes Measurement Information System (PROMIS®) Anxiety tool.
- Screening was conducted during routine visits at a specialized Turner syndrome clinic from October 2019 to March 2020.
Main Results:
- 65% of 92 Turner syndrome females (ages 8-62) exhibited elevated anxiety scores.
- No clear genotype-phenotype association was found, but elevated anxiety correlated with hearing deficits and multiple medical comorbidities.
- The PROMIS® Anxiety tool was found acceptable by 88% of surveyed patients, with 50% recommending screening every 6 months.
Conclusions:
- A high prevalence of anxiety symptoms necessitates routine screening in Turner syndrome populations.
- Validated tools like PROMIS® Anxiety can be effectively integrated into routine endocrinology visits for early identification and management.
- Timely recognition and intervention are vital, especially for milder anxiety presentations that might otherwise be overlooked.
Keywords:
AnxietyMood disturbancePatient-reported outcomes measurement information systemTurner syndromeMore Related Videos
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