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Updated: Sep 29, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Movement Is Life-Optimizing Patient Access to Total Joint Arthroplasty: Anemia and Sickle Cell Disease Disparities
Tamara Huff1, David Gibson, Mary I O'Connor
1From the Vigeo Orthopedics, LLC, Columbus, GA (Huff); Movement is Life, USA (Huff); Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT (Gibson); Vori Health, USA (O'Connor), Mayo Clinic, Jacksonville, FL (O'Connor).
Abstract:
Anemia and sickle cell anemia before surgery are often unrecognized medical comorbidities that can and should be addressed. Nearly 6% of the American population meets the criteria for anemia. The elderly, along with patients with renal disease, cancer, heart failure, or diabetes mellitus are more likely to be anemic. The most common form of anemia is due to iron deficiency, which can be easily treated before surgery. Sickle cell anemia occurs in 1 in 365 Black births and 1 in 16,300 Hispanic births, with 100,000 Americans currently living with sickle cell anemia. Patients who have anemia or sickle cell anemia are at increased risk for postoperative complications, including the need for blood transfusions and delayed healing. For those with sickle cell disease, surgeries can precipitate a sickle cell crisis. Patients with sickle cell anemia face barriers in accessing appropriate care; however, these patients can be optimized using preoperative red blood cell transfusions to dilute sickle cells and elevate the hemoglobin level. There should also be careful consideration and monitoring of the pain level of patients with sickle cell anemia in the perioperative period.
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