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Updated: Sep 29, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
Jing Cui1, Nanjing Cao2,3, Guochao Wang4
1Department of Biochemistry and Molecular Biology, Basic Medical College, Shanxi Medical University, Taiyuan 030001, China.
Methods:
We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression.
Results:
This study found microRNA-133b (miR-133b), as a HuR-sponged miRNA in GC cells. Downregulation of HuR can promote the expression of miR-133b and further affect the downstream cyclin CDC5L. The expressions of miR-133b were slightly lower in GC tissues than adjacent normal tissues.
Conclusion:
Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells.
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