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Updated: Sep 29, 2025

Measuring Neuromuscular Junction Functionality
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Fatigue and activity-dependent conduction block in neuromuscular disorders

Atsuko Tsuneyama1, Kazumoto Shibuya1, Sonoko Misawa1

  • 1Department of Neurology, Graduate School of Medicine, Chiba University Chiba, Japan.

Clinical Neurophysiology Practice
|March 22, 2022
PubMed
Summary

Fatigue in neuromuscular disorders like CIDP and SBMA stems from activity-induced conduction block. Objective assessments using nerve excitability testing and CMAP amplitudes can measure this peripheral fatigue.

Keywords:
Activity-dependent hyperpolarization and conduction blockChronic inflammatory demyelinating polyneuropathyFatigueSpinal and bulbar muscular atrophy

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