Role of D-mannose in urinary tract infections - a narrative review

Area of Science:

• Urology
• Microbiology
• Biochemistry

Background:

• Urinary tract infections (UTIs) are common bacterial infections with high recurrence rates.
• Antibiotic resistance is a growing concern, necessitating alternative treatments for UTIs.
• D-mannose, a simple sugar, is explored for its potential role in managing UTIs.

Purpose of the Study:

• To review the role of D-mannose in preventing and managing urinary tract infections (UTIs).
• To explore the mechanisms by which D-mannose may inhibit uropathogenic bacteria, particularly Escherichia coli.
• To summarize the current clinical evidence supporting D-mannose for UTI prophylaxis.

Main Methods:

• Literature review of studies on UTIs, E. coli pathogenesis, and D-mannose.
• Analysis of existing clinical evidence regarding D-mannose efficacy for UTI prevention and recurrence.
• Discussion of proposed mechanisms of action for D-mannose against uropathogenic E. coli.

Main Results:

• D-mannose is a potential prophylactic agent for recurrent UTIs.
• Evidence suggests D-mannose may inhibit the adhesion of E. coli to the urothelium.
• Further research is ongoing to fully elucidate D-mannose's role in UTI management.

Conclusions:

• D-mannose shows promise as an alternative or complementary therapy for recurrent UTIs.
• The anti-adhesion properties of D-mannose against E. coli are a key area of focus.
• D-mannose represents a potential strategy to combat antibiotic resistance in UTI treatment.