Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Structure

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Classification of Bones

Classification of Bones

The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical evaluation of a computer-assisted decision support and documentation system for the primary care of polytrauma patients.

Frontiers in digital health·2026

Same author

Medical treatment of osteoporosis in osteoporotic vertebral fractures - Results from the prospective EOFTT multicenter study.

Brain & spine·2026

Same author

Optimized OF-Score- Therapy Prediction in Successfully Treated Patients With Osteoporotic Spine Fractures Using Minimal Clinically Important Difference.

Global spine journal·2026

Same author

Treatment and outcome of osteoporotic OF3 vertebral fractures: results from the prospective multicenter EOFTT study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026

Same author

The bisegmental Cobb angle in osteoporotic spine fractures: Does it influence treatment decision or functional outcome?

Brain & spine·2026

Same author

Simultaneous Biarticular Growth Modulation for Ipsilateral Concomitant Valgus Deformities of the Knee and Ankle: Short-Term Results of a Case Series.

Children (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Sep 29, 2025

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Methods for bone quality assessment in human bone tissue: a systematic review.

Fangxing Wang^1,2, Leyu Zheng³, Jan Theopold³

¹ZESBO - Center for Research On Musculoskeletal Systems, Department of Orthopedic Surgery, Traumatology and Plastic Surgery, Leipzig University, Semmelweisstraße 14, 04103, Leipzig, Germany. fw92xadu@studserv.uni-leipzig.de.

Journal of Orthopaedic Surgery and Research

|March 22, 2022

Summary

This systematic review summarizes human bone quality assessment methods. Advanced imaging, mechanical testing, and compositional analysis are crucial for comprehensive bone quality evaluation.

Keywords:

Bone composition Bone quality Imaging Mechanical testing

More Related Videos

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

Related Experiment Videos

Last Updated: Sep 29, 2025

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

Area of Science:

Biomedical Engineering
Orthopedics
Materials Science

Background:

Bone quality is a critical factor in biomechanical studies and implant performance.
Existing literature describes various techniques for assessing bone quality.
A comprehensive understanding of these methods is needed to mitigate potential biases.

Purpose of the Study:

To systematically review and summarize current methods for assessing bone quality in human bone tissue.
To discuss the advantages and limitations of these diverse assessment techniques.

Main Methods:

Systematic literature review of PubMed and Web of Science databases (Jan 2000 - Apr 2021).
Screening and eligibility evaluation of references using PRISMA guidelines.
Inclusion of studies on imaging, mechanical testing, and compositional characterization of bone quality.

Main Results:

68 articles met inclusion criteria from 502 initially identified.
47 studies focused on imaging modalities (radiography, DEXA, CT, MRI).
19 studies utilized mechanical testing (traditional and indentation).
9 studies examined compositional characterization (e.g., degree of bone mineralization).
Data included 2898 human cadaveric bone specimens.

Conclusions:

Advanced techniques are vital for assessing bone morphology and microarchitecture.
Non-invasive imaging, mechanical testing, and compositional analysis should be integrated.
Complementary approaches are necessary for comprehensive human bone quality assessment.