Related Experiment Video

Updated: Sep 29, 2025

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.5K

Long-term Prognosis in Patients With Concomitant Acute Coronary Syndrome and Aortic Stenosis

Nicholas W S Chew1, Audrey Zhang2, Joy Ong2

  • 1Department of Cardiology, National University Heart Centre, National University Hospital, Singapore, Singapore.

The Canadian Journal of Cardiology
|March 22, 2022
PubMed

Insights

Patients with moderate or severe aortic stenosis (AS) and acute coronary syndrome (ACS) face high mortality. Early intervention is crucial to mitigate risks associated with concomitant moderate or severe AS in ACS patients.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Clinical Research

Background:

  • Aortic stenosis (AS) and acute coronary syndrome (ACS) share cardiovascular risk factors.
  • The co-occurrence of AS and ACS is rising due to an aging population.
  • Limited research exists on the prognosis of patients with both conditions.

Purpose of the Study:

  • To investigate the prognosis of patients presenting with ACS and concomitant AS.
  • To determine the impact of AS severity on mortality in ACS patients.
  • To identify predictors of mortality in this patient cohort.

Main Methods:

  • Retrospective single-centre cohort study.
  • Included consecutive patients with ACS and AS from January 2011 to March 2021.
  • Classified AS severity into mild, moderate, and severe based on echocardiogram; primary outcome was all-cause mortality.

Main Results:

  • Of 563 patients, 106 had severe AS, 193 moderate, and 264 mild.
  • All-cause mortality was significantly higher in moderate and severe AS groups compared to mild AS, both short-term and long-term.
  • Moderate or severe AS independently predicted all-cause mortality (HR 1.453 and 1.873, respectively).

Conclusions:

  • ACS patients with moderate or severe AS exhibit high long-term mortality, irrespective of ACS type.
  • High early mortality in moderate and severe AS necessitates urgent risk mitigation strategies.
  • Reduced left ventricular ejection fraction portends a poor prognosis, regardless of AS severity.
Abstract

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

18.7K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.2K

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
57
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
61
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
70
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
35
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
42
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
64