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Updated: Sep 29, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
The web-based "Right Review" tool asks reviewers simple questions to suggest methods from 41 knowledge synthesis
Krystle Amog1, Ba' Pham2, Melissa Courvoisier2
1Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Selecting the right knowledge synthesis method is challenging. The "Right Review" tool offers a free, practical solution, guiding users to 41 appropriate methods through simple questions for better research synthesis.
Area of Science:
- Health Sciences
- Information Science
- Research Methodology
Background:
- The increasing number of knowledge synthesis methods complicates the selection process for researchers.
- Choosing an appropriate method is crucial for the validity and reliability of evidence synthesis.
Purpose of the Study:
- To develop a web-based decision support tool,
- "Right Review", to guide users in selecting suitable knowledge synthesis methods.
- To provide practical assistance for researchers navigating the complex landscape of evidence synthesis.
Main Methods:
- Developed a decision support tool based on key dimensions of knowledge synthesis methods.
- Structured questions to differentiate between quantitative reviews and qualitative evidence synthesis (QES).
- Employed iterative design, usability testing, dissemination, and RE-AIM framework for evaluation.
Main Results:
- The "Right Review" tool recommends from 26 quantitative methods and 15 QES methods.
- Disseminated to over 4,600 users globally within 12 months.
- Evaluation confirmed the tool is fit-for-purpose and user-friendly.
Conclusions:
- "Right Review" simplifies the selection of appropriate knowledge synthesis methods.
- The tool addresses the challenge posed by the proliferation of synthesis methodologies.
- Offers a practical and accessible resource for evidence synthesis.
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