Infantile Choroid Plexus Papilloma with Multiple Peritumoral Cysts

Area of Science:

• Pediatric Neurosurgery
• Pediatric Oncology
• Neuropathology

Background:

• Infantile choroid plexus papilloma (CPP) is a rare brain tumor.
• A variant of CPP associated with multiple peritumoral cysts presents unique clinical challenges.
• Optimal management strategies for this rare variant remain largely undefined.

Purpose of the Study:

• To describe the clinical presentation, management, and outcomes of a rare variant of infantile choroid plexus papilloma associated with peritumoral cysts.
• To evaluate the efficacy of surgical resection of the solid tumor component in managing associated cysts and hydrocephalus.

Main Methods:

• Case presentation of a 9-month-old boy with a left lateral ventricle tumor.
• Detailed description of tumor characteristics, associated cysts, and hydrocephalus.
• Surgical resection of the solid tumor component and follow-up imaging.

Main Results:

• Total resection of the hypervascular solid tumor component led to shrinkage of peritumoral cysts and resolution of hydrocephalus.
• Histological examination confirmed CPP in the solid component and reactive gliosis in the cyst walls, without neoplastic cells.
• 12-month follow-up MRI showed stable cyst size, indicating long-term resolution.

Conclusions:

• Resection of only the solid part of the tumor is a viable management strategy for infantile CPP with nonenhancing peritumoral cysts.
• This approach can successfully resolve associated hydrocephalus and cysts without the need for permanent cerebrospinal fluid diversion.
• This case highlights a potentially less invasive management option for this rare pediatric brain tumor variant.