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ShellCoat, a Calcinated Calcium Solution, Effectively Inactivates SARS-CoV-2
Noritoshi Hatanaka1,2,3, Bingting Xu1, Yasuharu Yamashita4
1Graduate School of Life and Environmental Sciences, Osaka Prefecture University.
Biocontrol Science
|March 22, 2022
Summary
A calcinated calcium solution, ShellCoat, effectively inactivates SARS-CoV-2, the virus causing COVID-19. This powerful antiviral agent works even in the presence of organic matter like fetal bovine serum.
Area of Science:
- Virology
- Biochemistry
Background:
- Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) emerged in late 2019, causing a global pandemic.
- The need for effective SARS-CoV-2 inactivation methods is critical.
Purpose of the Study:
- To evaluate the antiviral efficacy of a calcinated calcium solution (ShellCoat) against SARS-CoV-2.
- To determine if ShellCoat retains antiviral activity in the presence of organic matter.
Main Methods:
- Concentrated SARS-CoV-2 was treated with ShellCoat for varying durations (10 seconds and 20+ seconds).
- Antiviral activity was assessed in the presence and absence of fetal bovine serum (FBS) as organic matter.
- Viral titers were measured using 50% tissue culture infective dose per mL (TCID50/mL).
Main Results:
- Treatment with ShellCoat for 10 seconds reduced viral titer by over 4 logs TCID50/mL.
- Treatment for 20 seconds or longer reduced viral titer below the detection limit (≤2.1 logs TCID50/mL).
- ShellCoat demonstrated significant antiviral activity even when organic matter (FBS) was present.
Conclusions:
- ShellCoat is a potent antiviral agent effective against SARS-CoV-2.
- The efficacy of ShellCoat is maintained in the presence of organic matter, suggesting practical applications.
