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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies

Upendarrao Golla1,2, Kishore Sesham3, Siva Dallavalasa4

  • 1Department of Medicine, Division of Hematology and Oncology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Non-Coding RNA
|March 22, 2022
PubMed

Insights

Long non-coding RNA ABHD11-AS1 is highly expressed in numerous cancers and shows significant clinical relevance. This review highlights its oncogenic potential and need for further mechanistic studies in cancer development and therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Aberrant expression of long non-coding RNAs (lncRNAs) is implicated in cancer development.
  • ABHD11 antisense RNA 1 (ABHD11-AS1) is a lncRNA gaining attention for its role in human malignancies.

Purpose of the Study:

  • To review and summarize the oncogenic potential of ABHD11-AS1 in various human cancers.
  • To highlight the clinical significance of ABHD11-AS1 in cancer prognosis, diagnosis, and treatment response.

Main Methods:

  • Literature review of studies investigating ABHD11-AS1 expression and function in cancer.
  • Analysis of reported mechanisms including miRNA sponging, pathway alteration, and epigenetic modifications.

Main Results:

  • ABHD11-AS1 is highly expressed in gastric, lung, breast, colorectal, thyroid, pancreas, ovary, endometrium, cervix, and bladder cancers.
  • ABHD11-AS1 acts as a biomarker for gastric cancer detection and has prognostic value in thyroid cancer.
  • Mechanisms include miRNA sponging, PI3K/Akt pathway modulation, and m6A modification, contributing to oncogenesis.

Conclusions:

  • ABHD11-AS1 exhibits significant oncogenic potential and clinical relevance across multiple cancer types.
  • Further mechanistic studies are crucial to understand its role in tumor development and to explore targeted therapeutic strategies.
Keywords:
ABHD11-AS1N6-methyladenosinePI3K/AktbiomarkercancerepigeneticslncRNAmiRNAsignaling pathwaystranscription

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