A sensitive electrochemical bisphenol A sensor based on molecularly imprinted polydopamine-coated Fe₃O₄ microspheres

Bisphenol A (BPA) interferes with the reproduction and endocrine system of humans and wild animals. For the detection of BPA, a sensitive and rapid detection method was established. BPA was imprinted on the surface of Fe₃O₄ nanoparticles through dopamine self-polymerization. After the removal of BPA, molecularly imprinted microspheres with BPA recognition cavity were formed. The electrochemical impedance response increased with BPA embedded in the molecular imprinting layer. The electrochemical signal was proportional to the concentration of BPA with a linear range from 1 × 10^-11 to 1 × 10^-3 M and a detection limit of 5.78 × 10^-12 M. The proposed biosensor was used to detect the BPA in vegetable oil indicating a promising application in food-field monitoring.