Related Experiment Video

Updated: Sep 29, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.6K

The role of miRNAs as a big master regulator of signaling pathways involved in lymphoblastic leukemia

Malihe Bagheri1, Parisa Zia Sarabi1, Mahdieh Mondanizadeh1

  • 1Department of Biotechnology and Molecular Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Journal of Cellular Physiology
|March 22, 2022
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cancer, impacting signaling pathways in acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Circulating miRNAs show promise as biomarkers and therapeutic targets for these leukemias.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs with significant roles as oncogenes or tumor suppressors in various cancers.
  • Acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are prevalent leukemia types with high mortality rates.
  • Aberrant signaling pathways are implicated in the pathogenesis of ALL and CLL.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in the essential signaling pathways of acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL).
  • To highlight circulating miRNAs as potential biomarkers for ALL and CLL.
  • To identify miRNAs as valuable therapeutic targets for leukemia treatment.

Main Methods:

  • Literature review of studies investigating miRNAs in ALL and CLL.
  • Analysis of miRNA involvement in key cancer-related signaling pathways.
  • Focus on circulating miRNAs as potential diagnostic and prognostic indicators.

Main Results:

  • Specific miRNAs are identified as crucial regulators of oncogenic and tumor-suppressive pathways in ALL and CLL.
  • Circulating miRNAs demonstrate potential as non-invasive biomarkers for leukemia detection and monitoring.
  • Dysregulated miRNAs in signaling pathways present opportunities for targeted therapies.

Conclusions:

  • MicroRNAs play a critical role in the molecular landscape of ALL and CLL.
  • Circulating miRNAs hold significant promise as biomarkers and therapeutic targets for improving leukemia patient outcomes.
  • Further research into miRNA-mediated signaling pathways can lead to novel treatment strategies.
Keywords:
acute lymphocytic leukemia (ALL)chronic lymphocytic leukemia (CLL)leukemiamiRNAsignaling pathway

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

303
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.8K

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K