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Updated: Sep 29, 2025
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Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
Published on: August 18, 2017
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Circular Dichroism Based Chirality Sensing with Supramolecular Host-Guest Chemistry
Mao Quan1, Xin-Yu Pang1, Wei Jiang1
1Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis and Department of Chemistry, Southern University of Science and Technology (SUSTech), Xueyuan Blvd 1088, Shenzhen, 518055, China.
Angewandte Chemie (International Ed. in English)
|March 22, 2022
Summary
Optical chirality sensing using circular dichroism and host-guest chemistry offers high-throughput analysis for drug discovery. This review covers sensor design, molecular recognition, and applications in asymmetric synthesis and reaction monitoring.
Area of Science:
- Analytical Chemistry
- Organic Chemistry
- Chemical Sensing
Background:
- Chirality analysis is crucial in drug discovery and chemical synthesis.
- Optical methods, particularly circular dichroism (CD), offer high-throughput screening capabilities.
- Host-guest chemistry provides a versatile platform for developing CD-based chirality sensors.
Purpose of the Study:
- To provide an overview of circular dichroism-based chiroptical sensing using host-guest chemistry.
- To analyze molecular recognition and chirality transfer principles in sensor design.
- To highlight applications and future directions in chirality analysis.
Main Methods:
- Classification of chirality sensors based on structural features.
- Analysis of molecular recognition and chirality transfer mechanisms.
- Demonstration of sensor applications using selected examples.
Main Results:
- Chirality sensors are categorized into three structural classes.
- Host-guest complexation enables effective chirality transfer and sensing.
- Sensors are applied to analyze products of asymmetric reactions and monitor reaction kinetics in real-time.
Conclusions:
- CD-based chiroptical sensing with host-guest chemistry is a promising field for high-throughput chirality analysis.
- This approach offers fast kinetics, broad substrate scope, and potential for sustainable development.
- Further research directions include sensor optimization and expanded applications.
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