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Updated: Sep 29, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Recent advances in the tandem copper-catalyzed Ullmann-Goldberg N-arylation-cyclization strategies
Jyoti M Honnanayakanavar1,2, Owk Obulesu1,2, Surisetti Suresh1,2
1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India. surisetti@iict.res.in.
Abstract:
N-Aryl bond formation under copper catalysis has played a pivotal role and has been extensively used as a key step in the total syntheses of several therapeutic molecules. The construction of fused N-heterocycles remains a flourishing area of research because of their potential importance in drug discovery research and functional materials. On the other hand, tandem reactions provide facile ways to access complex organic molecules by reducing the synthetic steps. This review article provides a detailed overview of the tandem reactions developed in the past two decades, comprising N-arylation-cyclization strategies, including mechanistic aspects, driven by copper catalysts to furnish biologically significant fused N-heterocyclic moieties. The protocols described enlighten the prominence of the copper-catalyzed N-arylation-cyclization tandem strategies; exploration in this direction may open new avenues, inspire the design of new and creative tandem reaction strategies, and may unveil novel transformations with unprecedented reaction mechanisms.
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