[New and rediscovered treatments for tuberculosis]

Area of Science:

• Infectious Diseases
• Microbiology
• Pharmacology

Background:

• Tuberculosis (TB) remains a significant global health threat.
• Recent advancements have introduced novel treatment strategies for TB.
• These include shorter regimens and new/repurposed antibiotics.

Purpose of the Study:

• To review recent developments in TB treatment.
• To explore the integration of shorter, oral therapies.
• To discuss the future role of precision medicine in TB management.

Main Methods:

• Literature review of recent clinical trials and research.
• Analysis of new and repurposed antibiotic efficacy.
• Examination of strategies for latent TB treatment.

Main Results:

• Shorter treatment regimens for latent TB improve adherence and reduce side effects.
• New and repurposed antibiotics offer effective, shorter treatments for drug-susceptible and drug-resistant TB.
• Atypical mycobacterioses also benefit from these advanced therapies.

Conclusions:

• Emerging TB treatments are predominantly oral and shorter.
• These therapies are expected to be combined with precision medicine.
• This integration promises more effective and personalized TB care.