C-H Bond Functionalization under Electrochemical Flow Conditions
Tamlal Pokhrel1, Bijaya B K1, Ramesh Giri1
1Central Department of Chemistry, Tribhuvan University, Kirtipur, 44618, Kathmandu, Nepal.
Chemical Record (New York, N.Y.)
|March 22, 2022
Summary
Flow electrolysis enables sustainable and efficient electrochemical C-H functionalization for creating carbon-carbon and carbon-heteroatom bonds. This method offers improved selectivity and reduced byproducts in organic synthesis.
Area of Science:
- Organic Synthesis
- Electrochemistry
- Sustainable Chemistry
Background:
- Electrochemical C-H functionalization is gaining prominence in organic synthesis.
- Flow electrolysis offers enhanced sustainability and efficiency over traditional methods.
Purpose of the Study:
- To provide a comprehensive review of flow electrolysis for C-H functionalization.
- To summarize recent advancements in constructing C-C and C-X bonds using this technique.
Main Methods:
- Utilizing flow electro-reactors for C-H functionalization reactions.
- Exploring applications in benzylic oxidation and synthesis of biologically active molecules.
Main Results:
- Flow electrolysis facilitates shorter reaction times and safer working conditions.
- The technique minimizes overoxidation and side product formation, improving selectivity.
- Electrochemical processes can be managed without supporting electrolytes.
Conclusions:
- Flow electrolysis is a powerful and sustainable tool for modern organic synthesis.
- This method enables efficient construction of diverse molecular architectures.
- It holds significant potential for accessing valuable chemical entities.
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