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Updated: Sep 29, 2025
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
Published on: September 9, 2020
Presence of cell-free fetal circRNA in maternal plasma
Yuxin Ran1,2,3, Ruixin Chen4, Yangyu Zhao5
1Department of Obstetrics, The First Afliated Hospital of Chongqing Medical University, Chongqing, China.
Introduction:
There is an urgent need to find novel stable cell-free fetal (cff-) RNA in the maternal circulation to facilitate the advance of non-invasive prenatal testing (NIPT) to more effectively avoid birth defects.
Methods:
CircRNA microarray was used to detect the cff-circRNA in plasma.
Results:
There were cff-circRNAs from the fetus in the peripheral blood of pregnant women and they persisted even until at least 24 h after delivery. In addition, we found that cff-circRNA might have a specific expression pattern in gestational disease.
Conclusions:
We demonstrated the presence of cff-circRNA in the maternal circulation, which may shed new light on the development of NIPT.
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