Related Experiment Video

Updated: Sep 29, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.0K

Innate and adaptive immune escape mechanisms of hepatitis B virus

Hua-Jun Zhao1, Yi-Fei Hu1, Qiu-Ju Han1

  • 1Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, Shandong Province, China.

World Journal of Gastroenterology
|March 23, 2022
PubMed

Insights

Chronic hepatitis B (CHB) persists due to complex immune interactions. Understanding HBV immune escape is key to developing new therapies for lasting viral control.

Area of Science:

  • Hepatology
  • Immunology
  • Virology

Background:

  • Chronic hepatitis B virus (HBV) infection presents a significant global health challenge with high mortality and morbidity.
  • Current treatments for chronic hepatitis B (CHB) can inhibit HBV but are limited by viral breakthrough due to resistance, non-adherence, and long treatment durations.

Purpose of the Study:

  • To review the immunological and biological characteristics of HBV.
  • To elucidate the immune escape mechanisms employed by HBV during persistent infection.
  • To discuss novel immune-based therapies for CHB treatment.

Main Methods:

  • Literature review of immunological and biological aspects of HBV.
  • Analysis of HBV immune escape mechanisms.
  • Overview of current and emerging immune-based therapeutic strategies for CHB.

Main Results:

  • Persistent CHB infection results from intricate interplay between HBV and host immune systems (innate and adaptive).
  • HBV utilizes specific mechanisms to evade host immune responses, contributing to chronicity.
  • Novel immune-based therapies show promise for achieving sustained viral clearance and immune control.

Conclusions:

  • Understanding HBV's immune evasion strategies is crucial for advancing CHB treatment.
  • Developing novel therapies targeting these immune mechanisms is essential for effective HBV eradication and long-term immune surveillance.

Keywords:
Adaptive immunityHepatitis B virusImmune toleranceInnate immunityTherapeutic strategy

More Related Videos

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.3K
Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

3.1K

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
180
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
996
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
77.5K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.2K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
5.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.6K