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The Interaction Between Non-Coding RNAs and Calcium Binding Proteins
Soudeh Ghafouri-Fard1, Jamal Majidpoor2, Hamed Shoorei3
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Calcium binding proteins (CBP) are a group of proteins mediating the effects of calcium on cellular functions. These proteins can regulate calcium levels inside the cells and contribute in several cellular functions through transporting this ion across cell membranes or decoding related signals. Recent studies have shown that several non-coding RNAs interact with CBPs to affect their expression or activity. The interactions between these transcripts and CBPs have implications in the pathoetiology of human disorders, including both neoplastic and non-neoplastic conditions. In the current review, we describe the interactions between three classes of non-coding RNAs (long non-coding RNAs, circular RNAs, and microRNAs) and a number of CBPs, particularly CAB39, S100A1, S100A4, S100A7 and S100P. This kind of interaction has been verified in different pathological contexts such as drug-induced cardiotoxicity, osteoblasts cytotoxicity, acute lung injury, myocardial ischemia/reperfusion injury, proliferative diabetic retinopathy, glomerulonephritis, as well as a wide array of neoplastic conditions.
Insights
Non-coding RNAs interact with calcium binding proteins (CBPs), influencing cellular functions and disease development. This review details these interactions in various human conditions, from cancer to organ injuries.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- Calcium binding proteins (CBPs) are crucial for cellular functions, regulating calcium ions and signaling pathways.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in gene expression regulation.
- Interactions between ncRNAs and CBPs are emerging as significant factors in cellular processes and disease.
Purpose of the Study:
- To review the interactions between three major classes of ncRNAs (lncRNAs, circRNAs, miRNAs) and specific CBPs.
- To highlight the implications of these interactions in various human pathologies.
- To provide a comprehensive overview of this rapidly evolving research area.
Main Methods:
- Literature review of studies investigating ncRNA-CBP interactions.
- Focus on specific CBPs like CAB39, S100A1, S100A4, S100A7, and S100P.
- Analysis of pathological contexts where these interactions are implicated.
Main Results:
- Detailed description of interactions between lncRNAs, circRNAs, and miRNAs with selected CBPs.
- Evidence of these interactions in diverse conditions including cancer, cardiotoxicity, lung injury, and kidney diseases.
- Identification of specific CBP targets such as CAB39, S100A1, S100A4, S100A7, and S100P.
Conclusions:
- ncRNA-CBP interactions play a critical role in the pathoetiology of numerous human diseases.
- Understanding these molecular mechanisms offers potential therapeutic targets for neoplastic and non-neoplastic conditions.
- Further research into ncRNA-CBP interplay is essential for advancing human health.
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