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Published on: July 12, 2011
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Eosinophilia complicated with venous thromboembolism: A case report
Wei-Qiang Su1, Yan-Zhong Fu2, Shu-Yan Liu3
1Department of Vascular Surgery, The Second People's Hospital of Jiaozuo City, Jiaozuo 454000, Henan Province, China.
World Journal of Clinical Cases
|March 23, 2022
Summary
Eosinophilia, a condition of increased eosinophils, can lead to dangerous blood clots. Early diagnosis and vigilance are crucial for managing this rare condition and preventing severe complications like thrombosis.
Area of Science:
- Hematology
- Neurology
- Vascular Medicine
Background:
- Eosinophilia, defined as >0.5 × 10^9/L eosinophils, is a systemic condition with diverse clinical presentations and unknown etiology.
- It frequently causes impaired organ function, making diagnosis challenging and often leading to delayed treatment.
- Rare manifestations, including cerebral venous sinus thrombosis and hemorrhage, are infrequently reported.
Observation:
- A 32-year-old woman presented with lower-limb edema and rash, later developing cerebral venous sinus thrombosis and deep vein thrombosis.
- Despite initial treatment for edema, her eosinophil count increased, and she experienced severe thrombotic events.
- The case involved eosinophilia, thrombocytopenia, and elevated D-dimer levels.
Findings:
- The patient developed extensive deep vein thrombosis and cerebral venous sinus thrombosis.
- Cerebral hemorrhage occurred, ultimately leading to brain death.
- Diagnosis was complicated by variable symptoms and delayed recognition of underlying eosinophilia.
Implications:
- Clinical vigilance is paramount for diagnosing eosinophilia due to its association with thrombus formation.
- Prompt identification and management are essential to prevent life-threatening thrombotic complications.
- This case highlights the critical need for awareness of rare eosinophilic disease manifestations.
