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Cryptogenic organizing pneumonia associated with pregnancy: A case report
Young Joo Lee1, Young Sun Kim2
1Department of Obstetrics and Gynecology, Kyung Hee University Medical Center, Seoul 02447, South Korea.
World Journal of Clinical Cases
|March 23, 2022
Summary
Cryptogenic organizing pneumonia (COP), a rare pregnancy complication, was diagnosed in a woman with recurrent pneumonia unresponsive to antibiotics. Prompt steroid treatment improved her symptoms, highlighting the need for differential diagnosis.
Area of Science:
- Pulmonology
- Obstetrics
- Radiology
Background:
- Cryptogenic organizing pneumonia (COP), previously bronchiolitis obliterans organizing pneumonia, is exceptionally rare during pregnancy.
- This case highlights COP diagnosis in a pregnant woman experiencing recurrent pneumonia refractory to antibiotic therapy.
Observation:
- A 35-year-old pregnant woman presented with pneumonia-like symptoms, initially treated with antibiotics with temporary relief.
- Recurrence of severe symptoms led to CT scans showing multifocal consolidation and ground-glass opacities.
- Bronchoalveolar lavage indicated a lymphocyte-predominant inflammatory response with a reduced CD4/CD8 ratio.
Findings:
- The patient received prednisolone, resulting in rapid improvement of dyspnea and other symptoms.
- Post-delivery transbronchial lung biopsy confirmed granulation tissue in small bronchioles, characteristic of COP.
- The case underscores the diagnostic challenge of COP mimicking atypical pneumonia in pregnancy.
Implications:
- Early differentiation of COP from community-acquired pneumonia is crucial for effective management in pregnant patients.
- This case emphasizes the importance of considering non-infectious inflammatory lung conditions in pregnant women with persistent respiratory symptoms.
- Timely diagnosis and steroid treatment can lead to favorable outcomes for both mother and fetus in cases of COP during pregnancy.
Keywords:
AntibioticsBronchiolitis obliterans organizing pneumoniaCase reportCorticosteroidCryptogenic organizing pneumoniaPregnancyMore Related Videos
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