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Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Related Experiment Video

Updated: Sep 29, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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The Interplay Between Coronavirus and Type I IFN Response.

Wenxiang Xue1, Chan Ding1,2, Kun Qian2

  • 1Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.

Frontiers in Microbiology
|March 23, 2022
PubMed
Summary

Coronaviruses evade the host

Keywords:
coronavirusimmune evasioninnate immunitytype I IFN responseviral replication

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Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Coronaviruses pose significant global threats to public health and animal health.
  • Understanding host-pathogen interactions is crucial for disease control and prevention.
  • Type I Interferon (IFN) response is a critical innate immunity component against viral infections.

Purpose of the Study:

  • To review and update current knowledge on coronavirus strategies for evading the type I IFN response.
  • To highlight the importance of understanding these interactions for vaccine and therapeutic development.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Literature search and analysis of scientific publications on coronaviruses and type I IFN evasion.

Main Results:

  • Coronaviruses have evolved diverse mechanisms to antagonize or evade the host's type I IFN response.
  • These evasion strategies are essential for viral replication and pathogenesis.
  • Specific viral factors and pathways involved in IFN antagonism are detailed.

Conclusions:

  • Elucidating coronavirus evasion tactics against type I IFN is vital for effective intervention strategies.
  • This knowledge will guide the development of novel vaccines and antiviral therapies against coronaviruses.