Peripheral Inflammatory Parameters in Patients with Antisocial Personality Disorder

Area of Science:

• Psychiatry
• Immunology
• Forensic Psychology

Background:

• Antisocial Personality Disorder (APD) is a complex mental health condition.
• The role of peripheral inflammation in the etiopathogenesis of APD requires further investigation.

Purpose of the Study:

• To compare peripheral inflammatory parameters between patients with APD and healthy controls.
• To explore correlations between inflammatory markers and symptom severity in APD.

Main Methods:

• Inclusion of 48 APD patients and 52 healthy controls.
• Measurement of white blood cell count, red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and basophil-to-lymphocyte ratio (BLR).
• Assessment of depression, anxiety, impulsivity, and hostility using standardized questionnaires.

Main Results:

• Significantly higher RDW and basophil levels were observed in APD patients compared to controls.
• Basophil-to-lymphocyte ratio (BLR) was higher in participants with alcohol use.
• Positive correlations were found between symptom severity scores and RDW, basophil, monocyte, and lymphocyte levels.

Conclusions:

• Inflammation may play a role in the development of APD.
• Elevated RDW and basophil levels are associated with APD and correlate with symptom severity.