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Urine Phthalate Levels and Liver Function in US Adolescents: Analyses of NHANES 2007-2016
Shiting Xiang1, Jie Dong1, Xun Li1
1Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, China.
Background:
Phthalates are non-persistent chemicals with endocrine-disrupting abilities widely used in a variety of consumer products. Evidence for the effects of phthalate exposure on liver function in adolescents is lacking.
Methods:
Data were analyzed from the combined 2007-2016 National Health and Nutrition Examination Survey (NHANES). Ultimately, a total of 1,650 adolescents aged 12-19 years were selected as the samples. Weighted linear regression was used to investigate the effects of urinary phthalate metabolites on liver function indexes.
Results:
Weighted Linear regression models showed that MCOP was negatively associated with TBIL (β = -0.0435, PFDR = 0.007), ΣDEHP (β = -0.0453, PFDR = 0.003) and MCOP (β = -0.0379, PFDR = 0.006) were negatively correlated with ALB, while MCPP was positively correlated with ALB (β = 0.0339, PFDR = 0.024), and MCOP was negatively correlated with TP (β = -0.0551; PFDR = 0.004).
Conclusions:
Phthalate metabolites were significantly but weakly associated with changes in liver function indicators among US adolescents. Future work should further examine these relationships.
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