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Updated: Sep 29, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

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Role of Chemerin/ChemR23 axis as an emerging therapeutic perspective on obesity-related vascular dysfunction

Yingying Xie1,2,3,4, Ling Liu5,6,7,8

  • 1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Journal of Translational Medicine
|March 23, 2022
PubMed

Insights

Obesity is linked to vascular dysfunction, with chemerin (an adipokine) and its receptor chemR23 playing key roles. This review explores their impact on blood vessel health and potential therapeutic targets.

Area of Science:

  • Cardiovascular Biology
  • Metabolic Disease Research
  • Adipokine Signaling

Background:

  • Epidemiological studies confirm a strong association between obesity and vascular dysfunction.
  • The precise molecular mechanisms linking obesity to impaired vascular function are not fully understood.
  • Adipokines secreted by expanded white adipose tissue in obesity are implicated in regulating vascular health.

Purpose of the Study:

  • To review current evidence on the chemerin/chemR23 signaling axis.
  • To elucidate the role of chemerin/chemR23 in regulating vascular function.
  • To identify therapeutic strategies targeting the chemerin/chemR23 pathway.

Main Methods:

  • Literature review of studies investigating chemerin and chemR23.
  • Analysis of signaling pathways influenced by chemerin/chemR23.
  • Synthesis of data on the impact of chemerin/chemR23 on vascular regulation.

Main Results:

  • Chemerin, a neo-adipokine, is elevated in obesity and binds to its receptor, chemR23.
  • The chemerin/chemR23 axis influences adipogenesis, inflammation, and vascular dysfunction.
  • Evidence suggests chemerin/chemR23 signaling pathways are critical in vascular health.

Conclusions:

  • The chemerin/chemR23 axis is a significant mediator between obesity and vascular dysfunction.
  • Targeting the chemerin/chemR23 pathway presents potential therapeutic avenues for obesity-related vascular diseases.
Keywords:
AdipokineChemR23ChemerinObesityVascular dysfunctionWhite adipose tissue

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