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Cryptococcal Meningitis Reported With Fingolimod Treatment: Case Series.

Maurizio Del Poeta1, Brian J Ward1, Benjamin Greenberg1

  • 1From the Department of Microbiology and Immunology (M.D.P.), Stony Brook University; Division of Infectious Diseases (M.D.P.), School of Medicine, Stony Brook University; Veterans Affairs Medical Center (M.D.P.), Northport, NY; Infectious Diseases Division (B.J.W.), Research Institute of the McGill University Health Centre, Montreal, QC, Canada; University of Texas Southwestern Medical Center (B.G.), Department of Neurology, Dallas, TX; Department of Neurology (B.H.), Klinikum Rechts der Isar, Technical University of Munich; Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; UCSF Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco; Novartis Healthcare Pvt. Ltd. (S.K., J.M.), Hyderabad, India; Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., A.M., T.H.), Basel, Switzerland; and Department of Neurology (J.R.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Neurology(R) Neuroimmunology & Neuroinflammation
|March 23, 2022
PubMed
Summary

Fingolimod (Gilenya) use in multiple sclerosis (MS) patients was associated with cryptococcal meningitis (CM), with an estimated incidence of 8 per 100,000 patient-years. Early detection of CM symptoms like headache is crucial for better outcomes.

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