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Recent advances in biosensor devices for HER-2 cancer biomarker detection
Supat Chupradit1, Saade Abdalkareem Jasim2, Dmitry Bokov3,4
1Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Abstract:
The human epidermal growth factor receptor 2 (HER-2) protein is a member of the epidermal growth factor receptor (EGFR or ErbB) family and is a transmembrane tyrosine kinase receptor. HER-2 is highly regulated in ovarian, lung, gastric, oral, and breast cancers. The low specificity, complexity, expensiveness and the lack of sensitivity are essential restrictions in traditional diagnosis methods such as FISH, immunohistochemistry and PCR and these disadvantages led to the need for more studies on alternative methods. Biosensor technology has greatly affected the quality of human life owing to its features including, sensitivity, specificity, and rapid diagnosis and monitoring of different patient diseases. In this review article, we examine various biosensors, considering that they have been categorized based on the transducers used including piezoelectric biosensors, optical sensors such as fluorescence and surface plasmon resonance, and electrochemical types for the diagnosis of HER-2 and the effectiveness of some drugs against that. Attention to developing some types of biosensor devices such as colorimetric biosensors for HER-2 detection can be an important point in future studies.
Insights
Biosensors offer sensitive and specific detection of human epidermal growth factor receptor 2 (HER-2), a key protein in various cancers. This review explores advanced biosensor technologies as alternatives to traditional HER-2 diagnostic methods.
Area of Science:
- Biomedical Engineering
- Molecular Diagnostics
- Cancer Biomarkers
Background:
- Human epidermal growth factor receptor 2 (HER-2) is a transmembrane tyrosine kinase receptor implicated in ovarian, lung, gastric, oral, and breast cancers.
- Traditional diagnostic methods like FISH, immunohistochemistry, and PCR for HER-2 detection face limitations including low specificity, complexity, high cost, and poor sensitivity.
- The need for improved diagnostic tools necessitates the exploration of alternative technologies for accurate HER-2 assessment.
Purpose of the Study:
- To review and analyze various biosensor technologies for the diagnosis of HER-2.
- To evaluate the effectiveness of biosensors in detecting HER-2 and monitoring drug efficacy against it.
- To highlight the potential of novel biosensor designs, such as colorimetric biosensors, for future HER-2 detection strategies.
Main Methods:
- Review of existing literature on biosensor applications for HER-2 detection.
- Categorization of biosensors based on transducer types: piezoelectric, optical (fluorescence, SPR), and electrochemical.
- Analysis of biosensor performance characteristics including sensitivity and specificity.
Main Results:
- Biosensor technology demonstrates significant potential for sensitive, specific, and rapid diagnosis and monitoring of HER-2.
- Various biosensor platforms, including electrochemical, optical, and piezoelectric, show promise for HER-2 detection.
- The review identifies key advantages of biosensors over traditional methods for HER-2 analysis.
Conclusions:
- Biosensors represent a promising alternative to conventional methods for HER-2 detection, offering enhanced diagnostic capabilities.
- Further development of biosensor devices, particularly colorimetric types, could significantly advance HER-2 diagnostics.
- Biosensor technology holds potential to improve patient outcomes through early and accurate HER-2 assessment and treatment monitoring.
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