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Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study
Florian Desgranges1, Eliana Tadini2, Aline Munting2
1Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland. florian.desgranges@chuv.ch.
Journal of General Internal Medicine
|March 23, 2022
Summary
More than half of patients with mild COVID-19 experience persistent symptoms for up to 10 months. Female gender and obesity are predictors of post-COVID-19 syndrome in these patients.
Area of Science:
- Infectious Diseases
- Public Health
- Epidemiology
Background:
- Mild COVID-19 can lead to persistent symptoms in outpatients.
- Prospective studies are needed to understand post-COVID-19 syndrome.
- Limited data exists on long-term symptoms after mild SARS-CoV-2 infection.
Purpose of the Study:
- To characterize post-COVID-19 syndrome in outpatients with mild COVID-19.
- To identify predictors of persistent symptoms after mild COVID-19.
- To analyze the association between symptoms and COVID-19 status.
Main Methods:
- Monocentric cohort study with prospective phone interviews (3-10 months post-visit).
- Included outpatients with PCR-confirmed COVID-19 (COVID-positive) and SARS-CoV-2 negative PCR (COVID-negative).
- Multivariate logistic regression used to evaluate associations and predictors, adjusted for covariates.
Main Results:
- 53% of COVID-positive (418 patients) and 37% of COVID-negative (89 patients) reported persistent symptoms.
- Fatigue, smell/taste disorder, dyspnea, and memory impairment were associated with COVID-19.
- Female gender and overweight/obesity predicted persistent symptoms in COVID-positive patients.
Conclusions:
- Over half of COVID-positive outpatients experience persistent symptoms up to 10 months post-mild illness.
- Only four specific symptoms were independently associated with COVID-19.
- Further research is needed to characterize post-COVID-19 syndrome and its societal impact.
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