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Towards Mapping Mouse Metabolic Tissue Atlas by Mid-Infrared Imaging with Heavy Water Labeling.

Xinwen Liu1, Lixue Shi1, Lingyan Shi1

  • 1Department of Chemistry, Columbia University, New York, NY, 10027, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 23, 2022
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Summary

This study introduces a novel metabolic imaging technique using heavy water (D2O) to create a detailed metabolic atlas of mouse tissues. This high-resolution method reveals organ- and cell-specific metabolic signatures, advancing our understanding of physiological and disease processes.

Keywords:
heavy water labelinginfrared imagingmetabolic heterogeneitymetabolismmultivariate analysis

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Area of Science:

  • Metabolomics
  • Molecular Imaging
  • Systems Biology

Background:

  • Understanding cellular metabolism is crucial for physiology and disease.
  • Current methods lack high-resolution, high-throughput metabolic profiling in mammalian tissues.
  • Developing advanced imaging tools is essential for creating metabolic atlases.

Purpose of the Study:

  • To develop and apply a novel metabolic imaging technique for creating a comprehensive metabolic tissue atlas.
  • To capture organ-, tissue-, and cell-type-specific metabolic profiles in mammalian systems.
  • To investigate metabolic changes during development and in disease states.

Main Methods:

  • Utilized mid-infrared imaging combined with heavy water (D2O) metabolic labeling.
  • Applied multivariate analysis to C-D vibrational spectra to identify metabolic signatures.
  • Employed unsupervised clustering for spatially-resolved metabolic profiling of brain tissues.

Main Results:

  • Successfully generated a large-scale metabolic atlas map across different mouse organs.
  • Identified distinct inter-organ and intra-tissue metabolic signatures.
  • Revealed in situ tissue- and cell-type-specific metabolic profiles in the brain.
  • Captured metabolic dynamics during brain development and characterized glioblastoma heterogeneity.

Conclusions:

  • The integrated platform enables high-resolution, high-throughput metabolic imaging.
  • This technique provides a powerful tool for mapping the metabolic tissue atlas in complex mammalian systems.
  • The approach facilitates the study of metabolic processes in development and disease.