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Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...

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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

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Published on: February 4, 2017

Calix[4]arene-Analogous Technetium Supramolecules.

Mamina Bhol¹, Guilhem Claude², Maximilian Roca Jungfer²

¹School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.

Inorganic Chemistry

|March 23, 2022

Summary

New technetium (Tc) and rhenium (Re) macrocycles, analogous to calix[4]arenes, were synthesized. These novel metallomacrocycles represent a significant advancement in supramolecular chemistry and coordination compounds.

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Area of Science:

Supramolecular Chemistry
Organometallic Chemistry
Coordination Chemistry

Background:

Calix[4]arenes are well-established macrocyclic compounds with a unique structure.
Technetium and rhenium complexes are of interest due to their diverse applications.

Purpose of the Study:

To synthesize novel calix[4]arene-analogous technetium and rhenium supramolecules.
To characterize the structure and properties of these new metallomacrocycles.

Main Methods:

Assembly of technetium supramolecules using (NBu4)[Tc2(μ-Cl)3(CO)6] and nitrogen-donor ligands.
Preparation of analogous rhenium macrocycles using [Re(CO)5X].
Characterization by spectroscopic methods and X-ray crystallography.

Main Results:

Successful synthesis of neutral homoleptic technetium macrocycles (1 and 2) with partial cone/cone conformation.
First example of fac-[Tc(CO)3]+ core-based metallocalix[4]arenes.
Preparation of structurally similar fac-[Re(CO)3]+ core-based macrocycles (3 and 4).

Conclusions:

The study presents the first metallocalix[4]arenes based on the fac-[Tc(CO)3]+ core.
The findings expand the scope of metallomacrocycle synthesis and characterization.
These novel technetium and rhenium macrocycles offer new platforms for supramolecular chemistry research.