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Updated: Sep 29, 2025

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization LNA flow-FISH: a Method for Bacterial Small RNA Detection
Published on: January 10, 2012
Synthesis and applications of bicyclic sugar modified locked nucleic acids: A review
Arkaja Goswami1, Ashok K Prasad2, Jyotirmoy Maity3
1Department of Chemistry, Shyam Lal College, University of Delhi, Delhi, India.
Abstract:
A large number of Locked Nucleic Acids (LNAs) with variety of modifications and restricted conformations have been developed in the last few decades. These modifications have significantly improved the biological properties of oligonucleotides, when LNAs moieties were incorporated into them. Herein, the synthesis and applications of these modified locked nucleic acids as antisense oligonucleotides are discussed.Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2022.2052316 .
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