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Related Concept Videos

Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acid Structure01:25

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Self-assembled Nucleic Acid Nanostructures for Biomedical Applications.

Xu Chang1, Qi Yang1, Jungyeon Lee1

  • 1Department of Chemistry, Rutgers University, Newark, NJ 07102, USA.

Current Topics in Medicinal Chemistry
|March 23, 2022
PubMed
Summary

Structural DNA nanotechnology offers programmable nanomaterials for biomedical research. This review explores DNA self-assembly strategies and custom nanostructures for precise control and biomolecule manipulation in medicine.

Keywords:
Biomedical applicationDNA origamiNanomaterialsNanostructuresNucleic acid nanotechnologyReconfigurationSelf-assembly

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Structural DNA nanotechnology enables the creation of self-assembled nanomaterials.
  • These nanomaterials are compatible with biosystems and offer nanoscale addressability and dynamic features.

Purpose of the Study:

  • To review DNA self-assembly strategies and designer nanostructures for biomedical applications.
  • To highlight the advantages of DNA nanotechnology in precise spatial control, biomolecule guidance, and developing reconfigurable nanodevices.

Main Methods:

  • Review of DNA self-assembly methods, ranging from simple DNA motifs to complex DNA origami architectures.
  • Discussion of the application of structural DNA nanotechnology in overcoming biomedical challenges.

Main Results:

  • DNA self-assembly provides precise spatial control for nanostructures.
  • DNA nanostructures can effectively mold and guide other biomolecules.
  • Reconfigurable DNA nanodevices offer solutions for complex biomedical challenges.

Conclusions:

  • Structural DNA nanotechnology is a powerful tool for developing custom nanostructures with desired functions for biomedical applications.
  • Diverse assembly strategies are key to creating functional DNA nanostructures.
  • Further research into challenges and opportunities will advance the use of DNA nanotechnology in medicine.