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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
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Thyroid dermopathy responds to teprotumumab therapy
Ricaurte Crespo-Trevino1,2, Jade Schiffman2, Shoaib Ugradar3
1Universidad de Monterrey, Monterrey, Mexico.
Endocrinology, Diabetes & Metabolism Case Reports
|March 23, 2022
Summary
Teprotumumab effectively treated thyroid dermopathy (TD) in patients with thyroid eye disease (TED). Most patients experienced improvement and sustained remission, offering a promising new treatment for this quality-of-life-impairing condition.
Area of Science:
- Endocrinology
- Dermatology
- Immunology
Background:
- Thyroid dermopathy (TD) is an uncommon thyroid disease manifestation impacting quality of life.
- Current TD treatments yield limited efficacy and high recurrence rates.
- Teprotumumab, a monoclonal antibody, successfully treats thyroid eye disease (TED).
Purpose of the Study:
- To evaluate teprotumumab's efficacy in treating thyroid dermopathy (TD).
- To explore teprotumumab as a potential therapeutic option for TD, given its success in TED.
Main Methods:
- Retrospective case series of four patients with both TD and TED.
- Patients received teprotumumab for TED and were assessed for TD improvement.
- Treatment involved multiple infusions of teprotumumab.
Main Results:
- All four patients showed improvement in TD after 2-3 teprotumumab infusions.
- Three out of four patients experienced no recurrence of TD post-treatment.
- Teprotumumab demonstrated a positive impact on TD symptoms and quality of life.
Conclusions:
- Teprotumumab may be an effective treatment for thyroid dermopathy (TD).
- The mechanism of action for TD resolution likely parallels that of TED regression.
- Further investigation is warranted for teprotumumab in managing TD, especially when quality of life is impaired.
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