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Vasculitis in Patients With Sarcoidosis: A Single-Institution Case Series of 17 Patients

Bradly A Kimbrough1, Kenneth J Warrington1, Hannah E Langenfeld2

  • 1From the Division of Rheumatology.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|March 23, 2022
PubMed

Insights

Vasculitis can affect any blood vessel size in patients with sarcoidosis. Most patients achieved remission with various treatments, regardless of vessel size, highlighting the importance of recognizing this association.

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Vascular Medicine

Background:

  • Vasculitis is a rare complication in patients diagnosed with sarcoidosis.
  • Limited data exists on the clinical characteristics and outcomes of vasculitis associated with sarcoidosis.

Purpose of the Study:

  • To describe the clinical features, treatments, and outcomes of vasculitis in patients with sarcoidosis.
  • To compare patients with large/medium vessel vasculitis (L/MVV) versus small vessel vasculitis (SVV).

Main Methods:

  • A single-institution retrospective review of medical records from January 1998 to December 2019.
  • Inclusion criteria: diagnosis codes for both sarcoidosis and vasculitis.
  • Vasculitis diagnosis confirmed by biopsy and/or arterial imaging.

Main Results:

  • Seventeen patients were identified: 9 with L/MVV and 8 with SVV.
  • Sarcoidosis onset preceded vasculitis in 44% of L/MVV and 38% of SVV cases.
  • Complete remission of vasculitis was achieved in most patients (8/9 L/MVV, 7/8 SVV) with diverse therapies.

Conclusions:

  • Sarcoidosis-associated vasculitis presents with comparable frequencies of L/MVV and SVV.
  • Effective remission of vasculitis is achievable with various treatments, irrespective of the affected vessel size.
  • Clinicians should maintain awareness of the potential co-occurrence of sarcoidosis and vasculitis.
Abstract

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