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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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[Unusual Organophosphate Poisoning: Transplacental Route]
Angie Lizeth Galíndez-González1, Tito Andrés Ortega-Toro1, Jenny Patricia Eraso Revelo1
1Hospital Universitario Departamental de Nariño, Pasto, Colombia.
Andes Pediatrica : Revista Chilena De Pediatria
|March 23, 2022
Summary
Neonatal organophosphate poisoning is rare and challenging to manage. This case highlights transplacental transfer, requiring intensive care, atropine, and leading to long-term neurological deficits in the infant.
Area of Science:
- Toxicology
- Neonatal Medicine
- Neurology
Background:
- Organophosphate poisoning is a global public health issue, particularly in developing nations.
- Chronic exposure during pregnancy can impact fetal neurodevelopment and growth.
Observation:
- A 36-week premature neonate exposed to maternal organophosphate poisoning 17 hours prior to birth presented with severe poisoning symptoms.
- The infant required intensive neonatal care, including mechanical ventilation, inotropes, and atropine treatment.
Findings:
- The neonate developed left hemiparesis and a convulsive syndrome, treated with phenobarbital.
- At 18 months, the child exhibited persistent hemiparesis and speech-language delay, despite initial recovery.
Implications:
- Neonatal organophosphate poisoning is exceptionally rare, necessitating individualized, multidisciplinary treatment approaches.
- The management of neonatal organophosphate poisoning lacks established guidelines, posing significant clinical challenges.
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