Related Experiment Video
Updated: Sep 29, 2025
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Effect of COVID-19 on cardiorenal axis: known or unknown universe?
G M Armentano1, M S Carneiro-Ramos1
1Laboratório de Imunologia Cardiovascular, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP, Brasil.
Insights
Coronavirus disease (COVID-19) is linked to heart and kidney damage, worsening patient outcomes. Understanding the cardiorenal syndrome in COVID-19 is crucial for better disease management and prognosis.
Area of Science:
- Cardiology
- Nephrology
- Infectious Diseases
Background:
- Coronavirus disease (COVID-19) is associated with multi-organ dysfunction.
- Cardiac and renal involvement are common in severe COVID-19, indicating a poor prognosis.
- Systemic inflammation in COVID-19 can damage vital organs, including the heart, kidneys, and blood vessels.
Purpose of the Study:
- To explore the relationship between COVID-19, cardiac abnormalities, and renal dysfunction.
- To investigate the impact of cardiorenal syndrome on COVID-19 prognosis.
- To highlight the importance of understanding cardiorenal interactions in SARS-CoV-2 infection.
Main Methods:
- Review of case reports of COVID-19 patients with cardiac and renal abnormalities.
- Analysis of the correlation between organ dysfunction and disease severity.
- Exploration of the cardiorenal syndrome in the context of COVID-19.
Main Results:
- COVID-19 patients with heart and kidney abnormalities showed a worse prognosis.
- The presence of cardiorenal syndrome was linked to increased disease severity.
- Case reports illustrate the detrimental effects of combined cardiac and renal compromise.
Conclusions:
- Cardiac and renal involvement are significant indicators of severe COVID-19.
- The cardiorenal syndrome plays a critical role in the prognosis of COVID-19 patients.
- Further research into the interplay between cardiac and renal systems during SARS-CoV-2 infection is warranted.
Abstract:
Recent findings have confirmed relationships between coronavirus disease (COVID-19) and multiple organ dysfunction. The prevalence of cardiac and renal involvement in COVID-19 has been increasingly reported and is a marker of severe disease that not only directly or indirectly affects the organs, but may also exacerbate the underlying comorbid illness. In addition, patients affected by the new coronavirus present a systemic inflammatory condition that results in damage to several tissues, especially the heart, kidneys, and vessels. It is well known that the heart and kidneys are closely related, so that any change in one of the organs can lead to damage to the other, establishing the so-called cardiorenal syndrome. Herein, we explore some case reports of patients with COVID-19 who had heart and kidney abnormalities, consequently resulting in worse prognosis of the disease. These results highlight the importance of understanding the cause and effect between the cardiac and renal systems and the course of early SARS-CoV-2 infection.
Related Concept Videos
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:22Heart Failure Drugs: Diuretics
01:11Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
01:29Acute Kidney Injury II: Pathophysiology
01:25Antihypertensive Drugs: Direct Renin Inhibitors
01:29Heart Failure II: Pathophysiology