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Updated: Sep 29, 2025

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

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[Novel therapeutic approaches for salivary gland carcinomas]

Lisa Nachtsheim1, Johanna Prinz2, Christoph Arolt3

  • 1Klinik und Poliklinik für HNO-Heilkunde, Kopf- und Hals-Chirurgie, Universität zu Köln Medizinische Fakultät, Koln, Germany.

Laryngo- Rhino- Otologie
|March 23, 2022
PubMed

Insights

New targeted therapies offer less toxic alternatives for salivary gland cancers, including NTRK inhibitors and axitinib. For advanced cases unresponsive to targeted treatments, platinum-based chemotherapy remains the standard care.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Drug Discovery

Context:

  • Salivary gland malignancies present unique treatment challenges.
  • Conventional chemotherapy has limitations in toxicity and efficacy.
  • Advancements in molecular pathology enable personalized therapeutic strategies.

Purpose:

  • To review emerging novel therapeutic options for salivary gland malignancies.
  • To highlight the role of targeted therapies and their advantages over traditional chemotherapy.
  • To discuss current treatment standards for advanced or recurrent disease.

Summary:

  • Novel targeted therapies, including NTRK inhibitors for secretory carcinomas and axitinib for adenoid cystic carcinomas, are emerging as less toxic alternatives.
  • Cross-entity therapeutics such as antiandrogenic therapy, HER2 inhibition, and PI3K inhibition show promise.
  • For metastatic or recurrent salivary gland carcinomas untreatable with targeted therapy, platinum-based chemotherapies remain the treatment of choice.

Impact:

  • These advancements offer improved treatment outcomes and reduced toxicity for patients with salivary gland cancers.
  • Personalized medicine approaches are transforming the management of rare cancers.
  • Further research into targeted therapies will likely expand treatment options and improve survival rates.

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