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Pervasive developmental disorders and immunological tolerance.

R D Todd

    Psychiatric Developments
    |January 1, 1986
    PubMed
    Summary
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    Early immune system problems, including maternal-fetal and self-tolerance issues, may cause cognitive deficits. This review explores immune tolerance in pervasive developmental disorders like autism.

    Area of Science:

    • Immunology
    • Neuroscience
    • Developmental Biology

    Background:

    • Studies suggest early immunological tolerance compromise, affecting maternal-fetal and self-tolerance, is linked to cognitive deficits.
    • Normal immune tolerance is crucial for development, and its disruption can lead to various pathological conditions.
    • Pervasive developmental disorders, such as infantile autism, are increasingly studied for potential immunological underpinnings.

    Purpose of the Study:

    • To review the mechanisms of normal immunological tolerance.
    • To discuss pathological deviations in tolerance relevant to neurodevelopmental disorders.
    • To examine immunological injury hypotheses for pervasive developmental disorders and associated research challenges.

    Main Methods:

    • Literature review of studies on immunological tolerance in humans and other species.

    Related Experiment Videos

  • Analysis of risk factors, family, twin, biochemical, anatomical, and immunological data related to pervasive developmental disorders.
  • Consideration of various immunological injury hypotheses for the etiology of these disorders.

    • Main Results:

    • Early compromise of immunological tolerance is associated with cognitive deficits.
    • Disruptions in maternal-fetal and self-tolerance may play a role in neurodevelopmental outcomes.
    • Several immunological hypotheses exist for the development of pervasive developmental disorders, but require further investigation.

    Conclusions:

    • Immune tolerance is critical for normal cognitive development.
    • Further research is needed to elucidate the specific immunological mechanisms underlying pervasive developmental disorders.
    • Technical challenges remain in validating immunological hypotheses for these complex conditions.