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Updated: Sep 29, 2025
An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
Published on: March 11, 2018
Relationship between treatment types and blood-brain barrier disruption in patients with acute ischemic stroke: Two
Youngbeom Seo1, Jonghoon Kim2, Min Cheol Chang3
1Department of Neurosurgery, College of Medicine, Yeungnam University, Daegu 42415, South Korea.
Background:
Blood-brain barrier (BBB) disruption plays an important role in the development of neurological dysfunction in ischemic stroke. However, diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are limited. Here, we describe two cases in which the usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different methods.
Case Summary:
The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy, although their sex was different. As a result of analysis by performing DCE-MRI, it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy (P = 3.3 × 10-7), whereas the average Ktrans of the contralateral hemisphere in both patients was similar (2.4 × 10-5 min-1 and 2.0 × 10-5 min-1). If reperfusion is achieved through thrombectomy, it may indicate that the penumbra can be saved and BBB recovery can be promoted.
Conclusion:
Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.
