Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pain01:20

Pain

666
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
666
Nociception01:44

Nociception

29.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.9K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

12.1K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
12.1K
Analgesia and Pain Management01:25

Analgesia and Pain Management

856
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
856

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.

Scientific reports·2025
Same author

Detrusor Underactivity and Acontractile Bladder Patients Performing Clean Intermittent Catheterization in a Single Tertiary Referral Center: What is Happening in Real Life?

International urogynecology journal·2025
Same author

Correction: Prolonged opioid use after single-level lumbar spinal fusion surgery in a Belgian population: a multicentric observational study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2025
Same author

Can EEG-Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Clinical Trial.

Brain and behavior·2025
Same author

Mourning for Silence: Bereavement and Tinnitus-A Perspective.

Journal of clinical medicine·2025
Same author

Infraslow Closed-Loop Brain Training for Anxiety and Depression (ISAD): A pilot randomised, sham-controlled trial in adult females with internalizing disorders.

Cognitive, affective & behavioral neuroscience·2025
Same journal

Mind the gender gap: how defining head trauma increases reporting in women aged 30-50.

Frontiers in neurology·2026
Same journal

Traditional Chinese medicine interventions for post-stroke cognitive impairment: an evidence mapping.

Frontiers in neurology·2026
Same journal

Acupuncture is independently associated with improved recovery in Guillain-Barré syndrome: a prospective observational study.

Frontiers in neurology·2026
Same journal

A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders.

Frontiers in neurology·2026
Same journal

Lumbar puncture opening pressure, brain network hub integrity, and delirium in herpes simplex virus encephalitis: a prospective cohort study.

Frontiers in neurology·2026
Same journal

Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.

Frontiers in neurology·2026
See all related articles

Related Experiment Video

Updated: Sep 29, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.8K

Pain and the Triple Network Model.

Dirk De Ridder1, Sven Vanneste2, Mark Smith3

  • 1Section of Neurosurgery, Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Frontiers in Neurology
|March 24, 2022
PubMed
Summary
This summary is machine-generated.

The triple network model unifies pain pathways, linking acute pain to suffering via the salience network. Chronic pain involves the default mode network, potentially leading to new personalized treatments.

Keywords:
acuteanterior cingulate cortexautonomicchroniccognitiveemotionalpaintriple network

More Related Videos

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

3.8K
Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

6.7K

Related Experiment Videos

Last Updated: Sep 29, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.8K
Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

3.8K
Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

6.7K

Area of Science:

  • Neuroscience
  • Pain Research
  • Psychiatry

Background:

  • Acute pain is a warning signal for tissue injury.
  • Chronic pain involves complex pathways: pain, suffering, and inhibition.
  • Existing models struggle to unify diverse pain experiences and comorbidities.

Purpose of the Study:

  • To present the triple network model as a unifying framework for understanding pain.
  • To explain how chronic pain integrates with self-perception and executive networks.
  • To explore the implications for neuropsychiatric disorders and personalized treatment.

Main Methods:

  • Conceptual framework integrating known pain pathways.
  • Description of interactions between default mode, salience, and central executive networks.
  • Analysis of how pain processing shifts in chronic conditions.

Main Results:

  • Painfulness and suffering are distinct but interconnected pathways.
  • Chronic pain involves functional connectivity between somatosensory cortex and the default mode network.
  • Aberrant network interactions underlie pain-related comorbidities and neuropsychiatric disorders.

Conclusions:

  • The triple network model provides a unified view of pain pathways and comorbidities.
  • Chronic pain becomes integrated into self-perception, affecting executive function.
  • This model facilitates personalized and customized therapeutic strategies for pain management.