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Related Experiment Video

Updated: Sep 29, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

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COVID-19 in Neonates with Positive RT-PCR Test. Systematic Review.

Heladia García1, Aldo Allende-López2, Paulina Morales-Ruíz2

  • 1Unidad de Investigación de Análisis y Síntesis de Evidencia, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Archives of Medical Research
|March 24, 2022
PubMed
Summary

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COVID-19 in newborns is usually mild, with most cases showing minimal symptoms. The study found a low mortality rate, suggesting a good prognosis for infected neonates.

Area of Science:

  • Infectious Diseases
  • Neonatal Medicine
  • Public Health

Background:

  • COVID-19, caused by SARS-CoV-2, presents with variable severity.
  • Neonatal cases of COVID-19 are often asymptomatic or mild.
  • Understanding COVID-19 in newborns is crucial for appropriate clinical management.

Purpose of the Study:

  • To systematically review published literature on COVID-19 in newborns.
  • To analyze clinical, radiological, laboratory, and outcome data.
  • To assess the impact of SARS-CoV-2 infection in neonates.

Main Methods:

  • Systematic literature search of PubMed and EMBASE databases (Dec 2019 - May 2021).
  • Inclusion of original studies reporting RT-PCR positive SARS-CoV-2 in newborns.
  • Data extraction and review by two independent investigators.
Keywords:
COVID-19NeonateNewbornNovel coronavirusSARS-CoV-2Systematic review

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Main Results:

  • 72 studies involving 236 newborns were analyzed.
  • Common symptoms included fever, respiratory, and gastrointestinal issues; 60.1% had mild/moderate disease.
  • Elevated C-reactive protein, procalcitonin, and lymphopenia were frequent laboratory findings; mortality was 1.7%.

Conclusions:

  • SARS-CoV-2 infection in newborns is predominantly mild to moderate.
  • The overall prognosis for neonates with COVID-19 is favorable.
  • Mortality is often linked to pre-existing comorbidities.