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Intussusception and COVID-19 in Infants: Evidence for an Etiopathologic Correlation

Federico Scottoni1, Giovanni Giuseppe Giobbe2, Elisa Zambaiti1

  • 1Department of Pediatric General Surgery, Regina Margherita Children's Hospital, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.

Pediatrics
|March 24, 2022
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause intestinal inflammation leading to intussusception in children. This study found viral evidence in intestinal tissues of two pediatric patients with SARS-CoV-2-associated intussusception.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Virology

Background:

  • Nonrespiratory manifestations of SARS-CoV-2 are increasingly recognized.
  • Ileocolic intussusception has been linked to SARS-CoV-2 in children, but direct viral evidence in intestinal tissue was lacking.

Purpose of the Study:

  • To investigate the potential role of SARS-CoV-2 in causing intestinal inflammation and intussusception in pediatric patients.
  • To provide pathological evidence of viral presence in the affected tissues.

Main Methods:

  • Case report of two pediatric patients with intussusception and SARS-CoV-2 infection from European tertiary centers.
  • Histopathological examination and molecular detection of SARS-CoV-2 in mesenteric and intestinal tissues.

Main Results:

  • Confirmed SARS-CoV-2 presence in the mesenteric and intestinal tissues of both pediatric patients.
  • The findings support a potential direct etiopathologic role for SARS-CoV-2 in pediatric intussusception.

Conclusions:

  • SARS-CoV-2 infection can be associated with intestinal inflammation leading to intussusception in children.
  • Direct detection of the virus in affected tissues provides crucial evidence for this association.

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